2026
Graspetide biosynthetic gene clusters in Porphyromonas gingivalis
Characterization of widespread graspetide biosynthetic gene clusters in the periodontal pathogen Porphyromonas gingivalis
Ashley K. Miles, Cole B. Matrishin, Kathryn M. Kauffman — Department of Oral Biology, School of Dental Medicine, University at Buffalo
All known graspetides are protease inhibitors. This work maps the biosynthetic gene clusters encoding them across P. gingivalis genomes, shows they ride on integrative and conjugative elements, and sets up the functional question: which host and bacterial proteases does this one actually inhibit?
Presented at
- University at Buffalo Student Research Day 2026 — School of Dental Medicine, Buffalo, NY
- 36th Annual Buffalo Conference on Microbial Pathogenesis — 27 May 2026, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY
- Gordon Research Conference on Proteases, Inhibitors and Therapeutics — June 2026, Renaissance Tuscany Il Ciocco, Lucca (Barga), Italy
Earlier presentations — co-authored
UB Student Research Day 2024 · IADR General Session 2024
Strain heterogeneity in subgingival plaque isolates of Fusobacterium nucleatum subspecies animalis
Takuma Suzuki, Ashley Miles, Stephanie Steimer, Ifeoluwaniayo Dada, Yasumitsu Shimizu, Patricia I. Diaz — Sunstar Inc. & Department of Oral Biology, University at Buffalo
ASTMH Annual Meeting 2020
Microbiome clusters associated with diarrheal outcomes are characterized by species diversity, systemic inflammation and antibiotic use in a Bangladeshi birth cohort
E. Ross Colgate, Korin M. Eckstrom, Rashidul Haque, Dorothy M. Dickson, Marya P. Carmolli, Ashley K. Miles, Masud Alam, Jeffrey I. Gordon, William A. Petri, Beth D. Kirkpatrick